Scientists find genetic variation associated with bipolar disorder

By Staff Writer

A new report in the American Journal of Human Genetics indicates that a previously unrecognized susceptibility factor of bipolar disorder has been discovered.

The research, which appears in the American Journal of Human Genetics, is based on a review of genome-wide associated studies (GWAS). This system allows experts to systematically sort through DNA samples to identify genetic variations. GWAS has previously been successful in spotting differences in common disorders such as type II diabetes, Crohn's disease and schizophrenia.

Using the GWAS and a follow-up examination of individuals with bipolar disorder, scientists discovered a genetic variation in the gene neurocan (NCAN) that was consistent in tens of thousands of patients with the condition. The researchers tested the function of NCAN in mice and found that the gene was associated with cognition and the regulation of emotions.

When the gene was removed from mice, the scientists observed some perturbation in mechanisms that are related to learning and memory.

Adolescents who suffer from mental disorders may benefit from participating in wilderness therapy programs, which are designed to provide help for troubled teens.