Scientists identify gene irregularity linked to bipolar disorder

By Staff Writer

A new report reveals that a brain protein called Piccolo may be the genetic variation that explains why many children inherit bipolar disorder (BPD) from their parents.

The study, which appears in the journal Biological Psychiatry, is based on the differences in gene expression patterns between people who have the mental condition and individuals who do not. The researchers identified 45 genetic variations between the two groups, and then used genetic markers to determine which alterations contributed the most to BPD.

They found that Piccolo is the likely culprit behind the condition. Piccolo is located at the endings of nerve cells and influences their ability to release chemical messengers to other areas of the brain. Scientists said that further testing will be needed in order to definitively link this gene expression to BPD. If confirmed, they hope that it will pave the way to new treatments for the mental condition.

Adolescents who suffer from BPD or other mental disorders may benefit from wilderness therapy programs, many of which are designed to provide help for troubled teens.